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(in pharmacokinetics) (MRT)

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(in pharmacokinetics) (MRT): Average time a drug molecule remains in the body or an organ after rapid intravenous injection. Note 1: Like clearance, its value is independent of dose. Note 2: After an intravenous bolus: tr = Am/ A where tr is the MRT, A is the area under the plasma concentration-time curve, and Am is the area under the moment curve. Note 3: For a drug with one-compartment distribution characteristics, MRT equals the reciprocal of the elimination rate constant. After

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