124i-a11 psca minibody
124i-a11 psca minibody - a radioconjugate composed of an affinity-matured antibody fragment, the a11 minibody, directed against human prostate stem cell antigen (psca), and conjugated with the radioisotope iodine I 124, that can potentially be used as an imaging agent for positron emission tomography (pet)/computed tomography (ct). The minibody moiety of iodine I 124-labeled anti-psca a11 minibody selectively targets and binds to psca. The psca-expressing tumor cells can then be visualized using pet/ct. Psca, a cell surface antigen expressed in normal human prostate and bladder, is overexpressed in a variety of cancers, including bladder, pancreatic, and prostate cancer. The a11 minibody is formed by the fusion of a single chain fv fragment with the immunoglobulin g1 ch3 domain. Also see iodine I 124-labeled anti-psca a11 minibody
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