124i fiau - a radioconjugate containing the nucleoside analog 2' fluoro 2' deoxy 1beta d arabinofuranosyl 5 iodouracil (fiau) labeled with the radioisotope iodine I 124 with positron emitting activity. Chemotherapeutic agents such as bortezomib may induce viral thymidine kinase expression in ebv and kaposi's sarcoma herpesvirus (kshv) associated tumors. Subsequent to chemotherapy induction of viral tk in these tumors, administered iodine I 124 fiau is phosphorylated by expressed viral tk, becoming selectively trapped within tk expressing tumor cells; these cells can then be visualized with positron emission tomography (pet). Viral tk is either not expressed or is expressed at very low levels in ebv and kaposi's sarcoma herpesvirus (kshv) associated tumors and may be activated by certain chemotherapeutic agents.
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