16k prl - a 16 kd n-terminal fragment of prolactin formed endogenously by cleavage of intact prolactin. Possessing anti-angiogenic properties, prolactin 16-kd fragment inhibits the pro-angiogenic effects of basal fibroblast growth factor (bfgf) and vascular endothelial growth factor (vegf) on endothelial cell proliferation, migration, and capillary organization. This agent also induces caspase-mediated endothelial cell apoptosis and upregulates the expression of plasminogen activator inhibitor-1 (pai-1); pai-1 inhibits the activity of urokinase, an enzyme essential to angiogenesis. (nci04)
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