Wikimd logo


W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
290,642 pages, 4,283,368 edits & 44,293,456 views.

Free unbiased diet, health and wellness info!

177lu-dtpa-omburtamab

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

177lu-dtpa-omburtamab - a radioimmunoconjugate consisting of omburtamab, a murine immunoglobulin g1 (igg1) antibody directed against the surface immunomodulatory glycoprotein human b7-homolog 3 (b7-h3, cd276), conjugated, via the chelating agent diethylenetriaminepentaacetic acid (dtpa), to the radioisotope lutetium lu 177, with potential antineoplastic activity. Upon intracerebroventricular administration of lutetium lu 177-dtpa-omburtamab, the omburtamab moiety binds to b7-h3 expressed on certain tumor cells. Upon binding, lutetium lu 177-dtpa-omburtamab delivers a cytotoxic dose of beta radiation to b7-h3-expressing cells. B7-h3, a type I transmembrane protein and a member of the b7 co-stimulatory protein superfamily, is overexpressed on certain tumor cell types and on various immune cells but is minimally expressed by normal human tissues. B7-h3 is a negative regulator of t-cell activation; its overexpression plays a key role in immuno-evasion, tumor cell invasion and metastasis, and is correlated with poor prognosis.

Up to date info

UpToDate

Latest research - 177lu-dtpa-omburtamab

PubMed
Clinical trials

Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on 177lu-dtpa-omburtamab for any updates.

 

177lu-dtpa-omburtamab is part of WikiMD's free ^articles!

^177lu-dtpa-omburtamab (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available