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177lu-pp-f11n - a radioconjugate composed of pp-f11n, a gastrin analog, conjugated to the beta-emitting radioisotope lutetium lu 177, with potential antineoplastic activity and potential use as an imaging agent for scintigraphy. Following intravenous administration, the pp-f11n moiety binds to the cholecystokinin-2 (cck-2) receptor. Subsequently, the cck-2 receptor-expressing tumor cells can be visualized scintigraphically. In addition, the radioisotope moiety delivers a cytotoxic dose of beta radiation to cck-2 receptor-expressing tumor cells. Cck-2 receptors are expressed on a variety of tumor cell types.

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Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on 177lu-pp-f11n for any updates.


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