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17 demethoxy 17 allylaminogeldanamycin mesylate

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17 demethoxy 17 allylaminogeldanamycin mesylate - the orally bioavailable mesylate salt of the 17 allylaminogeldanamycin (17 aag) small molecule inhibitor of several receptor protein tyrosine kinases with potential antiangiogenic and antineoplastic activities. Telatinib binds to and inhibits the vascular endothelial growth factor receptors (vegfrs) type 2 and 3, platelet derived growth factor receptor beta (pdgfrb) and c kit, which may result in the inhibition of angiogenesis and cellular proliferation in tumors in which these receptors are upregulated. These telatinib inhibited receptor protein tyrosine kinases are overexpressed or mutated in many tumor cell types and may play key roles in tumor angiogenesis and tumor cell proliferation. 17 aag is a synthetic analogue of the benzoquinone ansamycin antibiotic geldanamycin and has also been found to inhibit the molecular chaperone hsp90.

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Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on 17 demethoxy 17 allylaminogeldanamycin mesylate for any updates.


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