Logo


W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
13,859 pages, 4,141,228 edits & 40,048,959 views.

Free unbiased diet, health and wellness info!

18F-labeled mini-PEG spacered RGD dimer

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

A radiotracer containing a pegylated dimeric Arg-Gly-Asp (RGD) peptide (NH2-mini-PEG-E[c(RGDyK)]2 or PRGD2) radiolabeled with fluorine 18F-fluorobenzoate (18F-FB), with potential alphaVbeta3 integrin imaging activity upon positron emission topography (PET). Upon administration, the RGD moiety of 18F-labeled mini-PEG spacered RGD dimer (18F-FPRGD2) binds to alphaVbeta3 integrin. Upon PET, alphaVbeta3-expressing tumor cells can be visualized and the degree of tumor angiogenesis can be determined. This agent exhibits increased integrin receptor binding affinity, tumor cell uptake and increased radiolabeling yield as compared to the non-pegylated form (18F-FRGD2). Integrins, transmembrane glycoproteins, may be upregulated on proliferating tumor vessel endothelial cells and various cancer cells; their overexpression has been associated with neovascularization, differentiation, proliferation of tumor cells, metastasis and an overall poor prognosis.

Learn more about 18F-labeled mini-PEG spacered RGD dimer

Latest research - 18F-labeled mini-PEG spacered RGD dimer

PubMed
Clinical trials

External links

Wikipedia
Medicine icon
Medicine icon

This WikiMD article 18F-labeled mini-PEG spacered RGD dimer is a stub. If you are familiar with the topic 18F-labeled mini-PEG spacered RGD dimer, you can help us. Paid editors welcome!

 

18F-labeled mini-PEG spacered RGD dimer is part of WikiMD's free ^articles!

^18F-labeled mini-PEG spacered RGD dimer (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available