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18f-al-nota-matbbn - a radioconjugate containing a bombesin (bbn) peptide analog, derived from an unspecified grpr antagonist (matbbn) that targets the gastrin-releasing peptide receptor (grpr), and is linked to the radionuclide fluorine f 18 (18f), by the macrocyclic chelating agent, 1,4,7-triazacyclononane-n,n',n-triacetic acid (nota), through a method that first couples 18f to aluminum (al), with potential use in diagnostic imaging using positron emission tomography/computed tomography (pet/ct). Upon administration of fluorine f 18-al-nota-matbbn, the peptide moiety targets and binds to grpr. Upon pet/ct, grpr-expressing tumor cells can then be visualized. Grpr, also called bombesin receptor 2 (bb2), is a seven-transmembrane g protein-coupled receptor belonging to the bombesin receptor family. It is overexpressed in certain types of cancers. Bombesin is a peptide exhibiting high affinity for the gastrin-releasing peptide receptor (grpr).

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Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on 18f-al-nota-matbbn for any updates.


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