18f-alphavbeta6-binding peptide - a radiotracer composed of an integrin alphavbeta6 (avb6) binding peptide (bp) radiolabeled with the radionuclide fluorine f 18, with potential integrin avb6 imaging activity using positron emission tomography (pet). Upon administration, the fluorine f 18 integrin avb6-targeted peptide selectively binds to integrin avb6-positive cancer cells. During pet, avb6-expressing tumor cells can be visualized and the degree of tumor growth can be determined. Integrin avb6, a cell adhesion and signaling receptor, is upregulated in certain cancer cell types and has been associated with increased proliferation, migration and invasion of tumor cells.
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