18f-asis - a radioconjugate containing a tissue factor (tf) tracer, a derivative of activated factor vii (fviia), labeled with fluorine f 18, with potential use for tf-expressing tumor imaging using positron emission tomography (pet). Upon administration of fluorine f 18 active site inhibited factor viia (18f-asis), the active site inhibited factor viia (fviiai) moiety selectively targets and binds, with a much higher binding affinity than fviia, to tf. Upon pet imaging, tumor cells expressing tf can be visualized and assessed. Tf, a transmembrane glycoprotein, is overexpressed on certain tumor cell types and is correlated with tumor aggression and poor prognosis.
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