Logo


W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
13,672 pages, 4,140,287 edits & 38,337,121 views.

Free unbiased diet, health and wellness info!

18f-fluorobenzyl triphenyl phosphonium

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

18f-fluorobenzyl triphenyl phosphonium - a radioconjugate and cationic lipophilic agent consisting of fluorobenzyl triphenyl phosphonium (fbntp), labeled with the radioisotope fluorine f 18, with potential use as a tracer for both mitochondrial membrane potential (mmp) and apoptosis, and as a tumor imaging agent using positron emission tomography (pet). Upon administration, fluorine f 18 fbntp is taken up by cells and its uptake and accumulation within mitochondria is directly correlated with mmp. Apoptosis causes a loss of membrane potential across the inner mitochondrial membrane which decreases fbntp mitochondrial uptake. As apoptosis is suppressed in tumor cells, the fbntp uptake is increased as compared to normal cells. This allows, upon pet, for the imaging of cancer cells. As apoptotic-inducing chemotherapeutic agents cause a collapse of mmp, this agent can also be used to assess the response of tumor cells to those chemotherapeutic agents. Also see fluorine f 18 fluorobenzyl triphenyl phosphonium

Up to date info

UpToDate

Latest research - 18f-fluorobenzyl triphenyl phosphonium

PubMed
Clinical trials

Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on 18f-fluorobenzyl triphenyl phosphonium for any updates.

 

18f-fluorobenzyl triphenyl phosphonium is part of WikiMD's free ^articles!

^18f-fluorobenzyl triphenyl phosphonium (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available