18f choline - a radiotracer consisting of methylcholine labeled with the positron emitting radioisotope fluorine f 18 (18f fmch) with potential imaging use. Upon administration, 18f fluoromethylcholine incorporates into tumor cells through an active, carrier mediated transport mechanism for choline and then is phosphorylated intracellularly by choline kinase, an enzyme frequently upregulated in human tumors, yielding phosphoryl 18f fluoromethylcholine. In turn, phosphoryl 18f fluoromethylcholine is integrated into phospholipids in the cell membrane as part of phosphatidylcholine. As the proliferation of cancer cells is much higher than normal cells, tumor cells exhibit an increased rate of 18f fmch uptake and incorporation, allowing tumor imaging with positron emission tomography (pet).
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