18ffacbc - a radiotracer containing a synthetic amino acid analogue of l leucine radiolabeled with fluorine f 18 with potential diagnostic imaging use. Similar to most amino acids, fluciclovine f18 appears to enter cells through the energy independent l type amino acid transporter (lat) system. As an amino acid analogue, this agent is preferentially accumulated by tumor cells due to their increased metabolic needs; however, unlike naturally occurring amino acids, this non natural amino acid analogue radiotracer is not metabolized. Accordingly, fluciclovine f18 accumulates in tumor cells and can potentially be used to image tumors using positron emission tomography (pet).
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