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2-5a

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2-5a - an oligonucleotide synthesized from adenosine triphosphate (atp) by enzymes in the 2'-5'-oligoadenylate synthase family. The production of 2'-5'-oligoadenylate is stimulated by the presence of double stranded rna (dsrna) and binds to inactive monomeric forms of ribonuclease l (rnase l), thereby promoting rnase l dimerization and activation. Active rnase l degrades both cellular and viral rnas, which inhibits protein translation and leads to the abrogation of viral replication. 2'-5'-oligoadenylates play a key role in the innate immunity against viruses. Also see 2-5-oligoadenylate

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