2-mpp phosphopeptide-tetanus peptide vaccine
2-mpp phosphopeptide-tetanus peptide vaccine - a vaccine composed of phosphorylated peptides from the tumor associated antigens breast cancer anti-estrogen resistance-3 (bcar3) and insulin receptor substrate-2 (irs2) and a tetanus-derived peptide, with potential immunomodulating and antineoplastic activities. Upon administration of pbcar3/pirs2 phosphopeptide-tetanus peptide vaccine, the pbcar3/pirs2 phosphopeptide may stimulate the immune system to mount a cytotoxic t-lymphocyte (ctl) response against tumor cells expressing either phosphopeptide. The tetanus peptide serves as an immunoadjuvant and induces a helper t-cell response which may help stimulate an immune response against pbcar3 and pirs2-expressing melanoma tumor cells. Bcar3 and irs2 are upregulated in a variety of cancer cells.
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