20s proteosome - the 20s proteasome, as proteolytic core of the proteasome system, is essential in atp dependent ubiquitin protein complex degradation and in antigen processing in antigen presenting cell. It has 13-15 subunits each of which has three or four different peptidase activities. 26s proteasomes may be formed in an atp dependent fashion from a 20s proteasome and additional components, cf1 (660 kd), cf2 (250 kd) and cf3 (600 kd). The 20s proteasome interacts with additional subunits, pa700 and pa28, to form an atp-dependent multicatalytic proteinase complex (mpc) involved in the atp ubiquitin degradation pathway.
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