Logo


W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
13,947 pages, 4,144,360 edits & 41,585,119 views.

Free unbiased diet, health and wellness info!

3ap/famp

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

3ap/famp - a combination of the thiosemicarbazone 3 aminopyridine 2 carboxaldehyde (3 ap) and the nucleoside analogue fludarabine with antineoplastic activity. The agents in 3 ap/fludarabine, act synergistically to inhibit the enzyme ribonucleotide reductase.. Composed of two subunits, this enzyme catalyzes the rate limiting step in the conversion of ribonucleotides to deoxyribonucleotides. The 3 ap binds to and inactivates one subunit while fludarabine binds to and inactivates the other. Fludarabine also inhibits dna polymerase alpha and dna primase. At low concentrations, this agent arrests tumor cells in the s phase of the cell cycle; at higher concentrations, in the g0/g1 phase of the cell cycle. (nci04)

Up to date info

UpToDate

Latest research - 3ap/famp

PubMed
Clinical trials

Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on 3ap/famp for any updates.

 

3ap/famp is part of WikiMD's free ^articles!

^3ap/famp (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available