4-Hydroxycyclophosphamide
4-Hydroxycyclophosphamide
4-Hydroxycyclophosphamide (pronunciation: 4-Hy-drox-y-cyc-lo-phos-pha-mide) is a derivative of the chemotherapy drug cyclophosphamide. It is an active metabolite that plays a crucial role in the drug's pharmacological activity.
Etymology
The term "4-Hydroxycyclophosphamide" is derived from its chemical structure. The "4-Hydroxy" refers to the presence of a hydroxyl group at the fourth carbon in the cyclophosphamide molecule.
Pharmacology
4-Hydroxycyclophosphamide is produced in the liver by the action of cytochrome P450 enzymes on cyclophosphamide. It is then transported to the site of action where it is converted to its active form, phosphoramide mustard, which cross-links DNA and inhibits cell division.
Related Terms
- Cyclophosphamide: The parent drug from which 4-Hydroxycyclophosphamide is derived.
- Cytochrome P450: The enzyme responsible for the conversion of cyclophosphamide to 4-Hydroxycyclophosphamide.
- Phosphoramide mustard: The active form of 4-Hydroxycyclophosphamide that exerts the therapeutic effect.
- Chemotherapy: The use of drugs to treat diseases such as cancer.
See Also
External links
- Medical encyclopedia article on 4-Hydroxycyclophosphamide
- Wikipedia's article - 4-Hydroxycyclophosphamide
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