An orally bioavailable 4-thio modified 2-deoxycytidine analog, with potential antineoplastic activity. Upon administration of 4-thio-2-deoxycytidine (TdCyd), this cytidine analog is incorporated into DNA during replication and inhibits the activity of DNA methyltransferase 1 (DNMT1), which blocks DNA hypermethylation. This results in DNMT1 depletion, hypomethylation of DNA, and the reactivation of tumor suppressor genes that were silenced by hypermethylation; this results in antitumor activity and an inhibition of tumor cell proliferation.
Learn more about 4-thio-2-deoxycytidine
- Dailymed label info
- Scientific articles
- Drug portal 4-thio-2-deoxycytidine
- toxicity info on 4-thio-2-deoxycytidine
- FDA 4-thio-2-deoxycytidine