doctor


W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
13,941 pages, 4,144,327 edits & 41,513,907 views.

Free unbiased diet, health and wellness info!

4ab t1e28z positive t-cells

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

4ab t1e28z positive t-cells - autologous cd4 positive t-lymphocytes engineered to express the chimeric antigen receptor (car) t1e28z containing the erbb ligand, t1e, fused to the hinge region, transmembrane domain and endodomain of cd28 and the cd3zeta endodomain, with potential immunomodulating and antineoplastic activities. T1e, a chimeric polypeptide containing the n-terminus of human transforming growth factor (tgf)-alpha fused to the c-terminus of epidermal growth factor (egf), binds to erbb1 homodimers and heterodimers as well as erbb2/3 heterodimers, but not to erbb2 or erbb3 alone. Upon intratumoral administration, the promiscuous erbb ligand t1e of the t1e28z car-expressing autologous cd4-positive t lymphocytes binds to the specific erbb homo- and heterodimers on tumor cells. This induces selective toxicity in erbb-expressing tumor cells resulting in tumor cell lysis. Erbb1, erbb2 and erbb3, members of the epidermal growth factor receptor (egfr) family of receptor tyrosine kinases, are frequently overexpressed in solid tumors and play key roles in tumor cell proliferation and tumor angiogenesis.

Up to date info

UpToDate

Latest research - 4ab t1e28z positive t-cells

PubMed
Clinical trials

Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on 4ab t1e28z positive t-cells for any updates.

 

4ab t1e28z positive t-cells is part of WikiMD's free ^articles!

^4ab t1e28z positive t-cells (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available