WikiMD Resources 360

W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
13,941 pages, 4,144,327 edits & 41,513,907 views.

Free unbiased diet, health and wellness info!

5-alpha reductase inhibitors

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

Information about 5-alpha reductase inhibitors

The 5-alpha reductase inhibitors are a family of agents used to treat benign prostatic hypertrophy. They act by inhibiting the steroid 5-alpha reductase which catalyzes the conversion of testosterone to dihydrotestosterone. Dihydrotestosterone is an important prostatic growth factor and its inhibition causes gradual shrinkage of prostate.

Liver toxicity of 5-alpha reductase inhibitors

Both of the available agents lower serum concentrations of dihydrotestosterone without affecting serum testosterone and usually with minimal antiandrogenic effects.

History of 5-alpha reductase inhibitors

The 5-alpha reductase inhibitors in clinical use in the United States include two agents of similar chemical structure (azasteroids) and activity: finasteride (Proscar: 1992) and dutasteride (Avodart: 2001). Both agents cause a reduction in the size of the prostate, improve urinary flow and suppress prostate-specific antigen (PSA) levels. Both finasteride and dutasteride are associated with a low rate (<1%) of serum enzyme elevations during chronic therapy, which are usually mild-to-moderate in severity, self-limited in course, and rarely require dose modification or discontinuation. Neither of the 5-alpha reductase inhibitors in current use has been linked to clinically apparent acute liver injury.

The 5-alpha reductase inhibitors used for benign prostatic hypertrophy are discussed individually, with references on their hepatotoxicity given together at the end of this introductory section.

Drug class for 5-alpha reductase inhibitors

Drug Class: benign prostatic hypertrophy Agents, 5-Alpha Reductase Inhibitors

Alpha-blockers used to treat benign prostatic hypertrophy (BPH):

5-Alpha Reductase Inhibitors

Cost and Coupons - 5-alpha reductase inhibitors

Reviews for 5-alpha reductase inhibitors

Learn more about 5-alpha reductase inhibitors

Latest research - 5-alpha reductase inhibitors

Clinical trials

External links

Medicine icon
Medicine icon

This WikiMD article 5-alpha reductase inhibitors is a stub. If you are familiar with the topic 5-alpha reductase inhibitors, you can help us. Paid editors welcome!


5-alpha reductase inhibitors is part of WikiMD's free ^articles!

^5-alpha reductase inhibitors (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available