COVID-19 portal | Vitamin D | CDC | Vaccine | Keto | W8MD Diet

WikiMD is world's largest health encyclopedia with
28,594 pages, 4,000,354 edits & 34,551,964 views.

Unbiased health & wellness info for free & for all!

5-alpha reductase inhibitors

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

Information about 5-alpha reductase inhibitors

The 5-alpha reductase inhibitors are a family of agents used to treat benign prostatic hypertrophy. They act by inhibiting the steroid 5-alpha reductase which catalyzes the conversion of testosterone to dihydrotestosterone. Dihydrotestosterone is an important prostatic growth factor and its inhibition causes gradual shrinkage of prostate.

Liver toxicity of 5-alpha reductase inhibitors

Both of the available agents lower serum concentrations of dihydrotestosterone without affecting serum testosterone and usually with minimal antiandrogenic effects.

History of 5-alpha reductase inhibitors

The 5-alpha reductase inhibitors in clinical use in the United States include two agents of similar chemical structure (azasteroids) and activity: finasteride (Proscar: 1992) and dutasteride (Avodart: 2001). Both agents cause a reduction in the size of the prostate, improve urinary flow and suppress prostate-specific antigen (PSA) levels. Both finasteride and dutasteride are associated with a low rate (<1%) of serum enzyme elevations during chronic therapy, which are usually mild-to-moderate in severity, self-limited in course, and rarely require dose modification or discontinuation. Neither of the 5-alpha reductase inhibitors in current use has been linked to clinically apparent acute liver injury.

The 5-alpha reductase inhibitors used for benign prostatic hypertrophy are discussed individually, with references on their hepatotoxicity given together at the end of this introductory section.

Drug class for 5-alpha reductase inhibitors

Drug Class: benign prostatic hypertrophy Agents, 5-Alpha Reductase Inhibitors

Alpha-blockers used to treat benign prostatic hypertrophy (BPH):

5-Alpha Reductase Inhibitors

Cost and Coupons - 5-alpha reductase inhibitors

Reviews for 5-alpha reductase inhibitors

Learn more about 5-alpha reductase inhibitors

Latest research (Pubmed)


External links


WikiMD needs you!

This WikiMD article 5-alpha reductase inhibitors is a stub.
If you are a healthcare professional familiar with the topic 5-alpha reductase inhibitors, or
A subject matter expert or authority on 5-alpha reductase inhibitors, you can help us.
About | Mission | Paid editors welcome!

5-alpha reductase inhibitors is part of WikiMD's Physician reviewed^ articles available 4free, 4all, 4ever!
Medicine: Health - Encyclopedia‏‎‏‎ - Topics‏‎ -‏‎ Diseases‏‎ - Cancer - Rare diseases - Random Page Navigation: Drugs - Wellness - Obesity‏‎ - Diet - Ketogenic diet - W8MD weight loss diet - Editors: Recently Edited Pages - Alphabetical Order - Sponsors - USMLE The content on or accessible through WikiMD is for informational purposes only. WikiMD is not a substitute for professional medical advice. ^See full Disclaimers
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's insurance Weight loss program can HELP*