W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
13,947 pages, 4,144,360 edits & 41,585,119 views.

Free unbiased diet, health and wellness info!

5-aza-4’-thio-2’-deoxycytidine

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

An orally bioavailable, nucleoside analog and DNA methyltransferase I (DNMT1) inhibitor, with potential DNA hypomethylating and antineoplastic activities. Upon administration, 5-aza-4'-thio-2'-deoxycytidine (Aza-TdC) gets incorporated into DNA, where it binds to the active site of DNMT1, a maintenance methyltransferase that contributes to the hypermethylation and silencing of tumor suppressor genes. The formation of covalent DNMT1-DNA complexes inhibits DNMT1, prevents DNA methylation of CpG sites, causes CpG demethylation, and results in the re-expression and re-activation of silenced tumor suppressor genes. This inhibits tumor cell proliferation. DNMT1, overactivated in tumor cells, plays a key role in tumor cell proliferation.

Learn more about 5-aza-4’-thio-2’-deoxycytidine

Latest research - 5-aza-4’-thio-2’-deoxycytidine

PubMed
Clinical trials

External links

Wikipedia
Medicine icon
Medicine icon

This WikiMD article 5-aza-4’-thio-2’-deoxycytidine is a stub. If you are familiar with the topic 5-aza-4’-thio-2’-deoxycytidine, you can help us. Paid editors welcome!

 

5-aza-4’-thio-2’-deoxycytidine is part of WikiMD's free ^articles!

^5-aza-4’-thio-2’-deoxycytidine (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available