doctor


W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
13,672 pages, 4,140,288 edits & 38,337,121 views.

Free unbiased diet, health and wellness info!

68ga-nota-nfb

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

68ga-nota-nfb - a radioconjugate composed of a derivative of the cxcr4 peptide antagonist t140, in which the n-terminal 4-fluoro-benzoyl group (nfb) is substituted with the chelating agent 1,4,7-triazacyclononane-n,n',n-triacetic acid (nota) and radiolabeled with gallium ga 68, with potential cxcr4 imaging activity during positron emission topography (pet). Upon administration, gallium ga 68-nota-nfb selectively binds to cxcr4 and cxcr4-expressing tumor cells can then be visualized upon pet imaging. Cxcr4, a chemokine receptor belonging to the g protein-coupled receptor (gpcr) gene family, plays an important role in chemotaxis and angiogenesis, and is upregulated in several tumor cell types. Cxcr4 expression is correlated with tumor aggressiveness and high metastatic potential. Unmodified t140 binds non-specifically to red blood cells (rbcs); replacing the fluoro-benzoyl group with nota (nota-nfb) prevents the rbc binding almost entirely, while only minimally reducing the binding to cxcr4-positive tumor cells.

Up to date info

UpToDate

Latest research - 68ga-nota-nfb

PubMed
Clinical trials

Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on 68ga-nota-nfb for any updates.

 

68ga-nota-nfb is part of WikiMD's free ^articles!

^68ga-nota-nfb (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available