WikiMD is the world's largest medical encyclopedia with
13,858 pages, 4,141,175 edits & 39,920,702 views.
7beta-hydroxysteroid dehydrogenase type 5 inhibitor ASP9521
A selective, orally bioavailable inhibitor of 17beta-hydroxysteroid dehydrogenase type 5 (17bHSD5, aldo-keto reductase 1C3; AKR1C3), with potential antineoplastic activity. Upon administration, ASP9521 selectively binds to and inhibits the activity of 17bHSD5. This prevents the conversion of the adrenal androgens dehydroepiandrosterone and androstenedione into 5-androstenediol and testosterone. By blocking testosterone production, ASP9521 may inhibit the growth of testosterone-dependent cancers such as castration-resistant prostate cancer (CRPC). 17bHSD5, expressed both in normal prostate tissue and in prostate cancer (PC), plays a crucial role in persistent production of androgens despite castration; its expression is associated with increased malignancy of PC.
External links
This WikiMD article 7beta-hydroxysteroid dehydrogenase type 5 inhibitor ASP9521 is a stub. If you are familiar with the topic 7beta-hydroxysteroid dehydrogenase type 5 inhibitor ASP9521, you can help us. Paid editors welcome!
7beta-hydroxysteroid dehydrogenase type 5 inhibitor ASP9521 is part of WikiMD's free ^articles!
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
 Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available |
