8-oxo-dg - a major spontaneous oxidized derivative of 2'-deoxyguanosine and a biomarker of oxidative dna damage. 8-hydroxy-2'-deoxyguanosine (8-oxo-dg) is formed through the reaction of guanine with reactive oxygen species. Although normally repaired and removed by the base excision repair mechanism, 8-oxo-dg can potentially mispair with deoxyadenine leading to g-to-t transversion mutations, which cause frequent recombinations and single nucleotide polymorphisms (snps) in the human genome. The concentration of 8-oxo-dg within a cell is a measurement of oxidative stress and may thus be used to assess the extent of physiological and environmental damage to dna. Also see 8-hydroxy-2-deoxyguanosine
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