9ac colloidal dispersion
- a colloidal dispersion formulation of 9 aminocamptothecin, a water insoluble camptothecin derivative. Aminocamptothecin binds to the nuclear enzyme topoisomerase I, thereby inhibiting repair of single strand dna breakages. Because the terminal lactone ring of aminocamptothecin required for the agent's antitumor activity spontaneously opens under physiological conditions to an inactive carboxy form, the drug must be administered over an extended period of time to achieve effective cytotoxicity.
Up to date info
Latest research - 9ac colloidal dispersion
Source: Data courtesy of the U.S. National Library of Medicine. Since the data might have changed, please query MeSH on 9ac colloidal dispersion for any updates.