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Information about Felodipine

Felodipine is a second generation calcium channel blocker and commonly used antihypertensive agent.

Liver safety of Felodipine

Felodipine therapy has been associated with a low rate of serum enzyme elevations, but has not been convincingly linked to instances of clinically apparent, acute liver injury.

Mechanism of action of Felodipine

Felodipine (fe loe' di peen) belongs to the dihydropyridine group of calcium channel blockers (with amlodipine, isradipine and nifedipine) and is used primarily in the therapy of hypertension. Like other calcium channel blockers, felodipine acts by blocking the influx of calcium ions into vascular smooth muscle and cardiac muscle cells during depolarization, which results in arterial vasodilation and decrease in cardiac work and oxygen consumption.

FDA approval information for Felodipine

Felodipine was approved in the United States in 1991 and currently more than 3 million prescriptions are filled yearly. The current sole indication is treatment of hypertension, either alone or with other antihypertensive agents.

Dosage and administration for Felodipine

Felodipine is available in multiple generic forms and under the commercial name Plendil in 2.5, 5 and 10 mg extended release tablets. The recommended dose in adults is 2.5 to 10 mg once daily, generally starting at the lowest dose and adjusting upward.

Side effects of Felodipine

Like other calcium channel blockers, felodipine is generally well tolerated, but side effects can include dizziness, flushing, headache, fatigue, nausea, diarrhea, peripheral edema, palpitations and rash.

calcium channel blockers

Antihypertensive agents

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