AMG 706
AMG 706
AMG 706 (pronounced as A-M-G Seven-Oh-Six) is an investigational small molecule inhibitor that targets multiple kinases, including vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR), and stem cell factor receptor (c-Kit).
Etymology
The term AMG 706 is a proprietary name given by Amgen, a multinational biopharmaceutical company. The 'AMG' stands for Applied Molecular Genetics, the original name of the company, while '706' is a unique identifier for the drug candidate.
Mechanism of Action
AMG 706 works by inhibiting the activity of certain protein kinases, which are enzymes that add phosphate groups to other proteins. By blocking these kinases, AMG 706 can prevent the growth of new blood vessels that tumors need to grow and spread, a process known as angiogenesis.
Related Terms
- Angiogenesis inhibitor: A substance that inhibits the growth of new blood vessels (angiogenesis), used to prevent the growth of tumors and to treat cancer and age-related macular degeneration.
- Kinase inhibitor: A type of drug that blocks certain enzymes known as kinases.
- Small molecule: A low molecular weight organic compound that may regulate a biological process, with a size on the order of 1 nm.
- VEGFR: Vascular endothelial growth factor receptor, a part of the system that regulates cell growth.
- PDGFR: Platelet-derived growth factor receptor, a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family.
- c-Kit: A protein that in humans is encoded by the KIT gene. It is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types.
External links
- Medical encyclopedia article on AMG 706
- Wikipedia's article - AMG 706
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