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AML with myelodysplasia-related features

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Other Names: AML with multilineage dysplasia; Acute myeloid leukemia with multilineage dysplasia; Acute myeloid leukaemia with myelodysplasia-related features

Clinical features

A type of acute myeloid leukemia in which at least 20% of a patient’s blood or bone marrow is myeloblasts (immature white blood cells) and the patient has one of the following conditions: 1) has had myelodysplastic syndrome (MDS) or a myelodysplastic/myeloproliferative neoplasm (MDS/MPN) before, 2) cells that have changes in certain chromosomes that are similar to those found in MDS, or 3) at least 50% of the cells (of at least two types of blood cells) are abnormal.

Prognosis

Acute myeloid leukemia with myelodysplasia-related changes usually occurs in older adults and has a poor prognosis. Also called AML-MRC.

NIH genetic and rare disease info

AML with myelodysplasia-related features is a rare disease.


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