doctor


W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
13,858 pages, 4,142,535 edits & 40,172,680 views.

Free unbiased diet, health and wellness info!

APE1/Ref-1 redox inhibitor APX3330

From WikiMD's free health, diet & wellness encyclopedia
Jump to navigation Jump to search

An orally bioavailable inhibitor of apurinic/apyrimidinic endonuclease 1/reduction-oxidation (redox) effector factor-1 (APE1/Ref-1; APEX1), with potential anti-angiogenic and antineoplastic activities. Upon administration, the APE1/Ref-1 Inhibitor APX3330 selectively targets and binds to APE1/Ref-1. This inhibits the redox-dependent signaling activity of APE1/Ref-1, by preventing the reduction and activation of numerous APE1/Ref-1-dependent oncogenic transcription factors (TFs), such as nuclear factor kappa B (NF-kB), AP-1, STAT3, p53, NRF2 and HIF-1alpha, that are involved in signaling, cell proliferation, tumor progression and survival of cancer cells. Therefore, this agent inhibits the activation of multiple TF-mediated signaling pathways and inhibits tumor cell proliferation and survival. APE1/Ref-1, a multifunctional protein overexpressed in many cancer cell types, plays a key role as a redox regulator of transcription factor activation and in base excision repair upon DNA damage. It drives cancer cell proliferation, migration, drug resistance, angiogenesis and inflammation and its expression level correlates with increased tumor aggressiveness and decreased patient survival. APX3330 specifically blocks the redox activity of APE1/Ref-1 and does not affect its ability to act as a DNA repair endonuclease.

Learn more about APE1/Ref-1 redox inhibitor APX3330

Latest research - APE1/Ref-1 redox inhibitor APX3330

PubMed
Clinical trials

External links

Wikipedia
Medicine icon
Medicine icon

This WikiMD article APE1/Ref-1 redox inhibitor APX3330 is a stub. If you are familiar with the topic APE1/Ref-1 redox inhibitor APX3330, you can help us. Paid editors welcome!

 

APE1/Ref-1 redox inhibitor APX3330 is part of WikiMD's free ^articles!

^APE1/Ref-1 redox inhibitor APX3330 (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available