ATP1A2
ATP1A2
ATP1A2 (pronounced A-T-P-One-A-Two), also known as the Alpha-2 subunit of the Na+/K+ ATPase is a protein that in humans is encoded by the ATP1A2 gene.
Etymology
The term ATP1A2 is derived from the abbreviation of Adenosine Triphosphate (ATP), the primary energy currency of the cell, and 1A2, which signifies the specific isoform of the protein.
Function
ATP1A2 is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle.
Clinical Significance
Mutations in the ATP1A2 gene are associated with familial hemiplegic migraine type 2 (FHM2) and also with a form of cortical malformation known as polymicrogyria.
Related Terms
- Adenosine Triphosphate (ATP)
- Familial Hemiplegic Migraine (FHM)
- Polymicrogyria (PMG)
- Electrochemical gradient
- Osmoregulation
- Sodium-coupled transport
External links
- Medical encyclopedia article on ATP1A2
- Wikipedia's article - ATP1A2
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