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What abametapir?

Abametapir (Xeglyze) is a prescription medicine used to get rid of head lice in people 6 months of age and older.

Abametapir skeletal.svg

What are the uses of this medicine?

  • This medicine is indicated for the topical treatment of head lice infestation in patients 6 months of age and older.
  • This medicine should be used in the context of an overall lice management program:
  • Wash (with hot water) or dry-clean all recently worn clothing, hats, used bedding and towels
  • Wash personal care items such as combs, brushes, and hair clips in hot water
  • Use a fine-tooth comb or special nit comb to remove dead lice and nits

How does this medicine work?

  • Abametapir (5,5’-dimethyl 2,2’-bipyridinyl) is a metalloproteinase inhibitor.
  • Metalloproteinases have a role in physiological processes critical to egg development and survival of lice.

Who Should Not Use this medicine ?

  • Use is not recommended in pediatric patients under 6 months of age because of the potential for increased systemic absorption.

Is this medicine FDA approved?

  • It was approved for use in the United States in 2020.

How should this medicine be used?

  • For topical use only.
  • Not for oral, ophthalmic, or intravaginal use.
  • Shake well before use.
  • Apply XEGLYZE to dry hair in an amount sufficient (up to the full content of one bottle) to thoroughly coat the hair and scalp.
  • Avoid contact with eyes.
  • Massage XEGLYZE into the scalp and throughout the hair; leave on the hair and scalp for 10 minutes and then rinse off with warm water.
  • Treatment with XEGLYZE involves a single application.
  • Discard any unused product.
  • Do not flush contents down sink or toilet.

What are the dosage forms and brand names of this medicine?

This medicine is available in fallowing doasage form:

  • As lotion Lotion, 0.74% [weight by weight]

This medicine is available in fallowing brand namesː


What side effects can this medication cause?

Common possible side effects of this medicine include:

  • erythema
  • rash
  • skin burning sensation
  • contact dermatitis
  • vomiting
  • eye irritation
  • pruritus
  • hair color changes

What special precautions should I follow?

  • Administer only under direct supervision of an adult.
  • systemic exposure to benzyl alcohol has been associated with serious adverse reactions and death in neonates and low birth-weight infants.
  • Safety and effectiveness in pediatric patients below the age of 6 months have not been established.

What to do in case of emergency/overdose?

  • Ingestion of benzyl alcohol in large quantities may result in gastrointestinal (nausea, vomiting, diarrhea) and central nervous system (headache, ataxia, convulsions, coma) adverse reactions.
  • Serious adverse reactions may include respiratory depression and death.
  • If accidentally swallowed, advise the patient or the caregiver to call their Poison Control Center at 1-800-222-1222.

Can this medicine be used in pregnancy?

  • There are no available data on XEGLYZE use in pregnant women to evaluate for a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes.

Can this medicine be used in children?

  • The safety and effectiveness of XEGLYZE have been established in pediatric patients 6 months of age and older.
  • The safety and effectiveness of XEGLYZE have not been established in pediatric patients below the age of 6 months.
  • XEGLYZE is not recommended in pediatric patients under 6 months of age.

What should I know about storage and disposal of this medication?

  • Store upright at room temperature, 20°C to 25°C (68°F to 77°F), with allowable excursions between 15°C and 30°C (59°F and 86°F).
  • Do not refrigerate or freeze.

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