Liposomal amphotericin B
A liposome-encapsulated formulation of the polyene antifungal antibiotic amphotericin B.
How is it produced?
It is produced by the bacterium Streptomyces nodosus with antifungal activity.
Mechanism of action
Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, and alters cell membrane integrity, resulting in leakage of intracellular components and cell rupture.
This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells.
Benefits of liposomal amphotericin B
Compared to amphotericin B alone, liposomal delivery of amphotericin B allows for a greater drug concentration in target tissues while decreasing systemic side effects.
Amphotericin B-lipid complex
US brand name
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Latest research (Pubmed)