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Liposomal amphotericin B

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A liposome-encapsulated formulation of the polyene antifungal antibiotic amphotericin B.

Amphotericin B
Amphotericin B

How is it produced?

It is produced by the bacterium Streptomyces nodosus with antifungal activity.

Mechanism of action

Amphotericin B binds to ergosterol, an essential component of the fungal cell membrane, and alters cell membrane integrity, resulting in leakage of intracellular components and cell rupture.

Oxidative damage

This agent may also induce oxidative damage in fungal cells and has been reported to stimulate host immune cells.

Benefits of liposomal amphotericin B

Compared to amphotericin B alone, liposomal delivery of amphotericin B allows for a greater drug concentration in target tissues while decreasing systemic side effects.

Synonym

Amphotericin B-lipid complex

US brand name

Abelcet AmBisome

Acronym

L-AMB

Learn more about Liposomal amphotericin B

Latest research (Pubmed)

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