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Abexinostat

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Abexinostat (INN,[1] formerly PCI-24781) is an experimental drug candidate for cancer treatment.[2] It was developed by Pharmacyclics and licensed to Xynomic. and is in Phase II clinical trials for B-cell lymphoma.[3] Pre-clinical study suggests the potential for treatment of different types of cancer as well.[4][5][6][7]

Abexinostat exerts its effect as a pan-histone deacetylase inhibitor[8][9] and inhibits RAD51, which is involved in repairing DNA double strand breaks.[10]

References

  1. WHO Drug Information, Vol. 25, No. 2, 2011
  2. Abexinostat, NCI Cancer Dictionary
  3. Abexinostat HCl (PCI-24781), PanHDAC-inhibitor Archived 2013-10-27 at the Wayback Machine, Pharmacyclics

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