W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
13,854 pages, 4,142,505 edits & 40,133,090 views.

Free unbiased diet, health and wellness info!

Aripiprazole

From WikiMD's free health, diet & wellness encyclopedia
(Redirected from Abilify)
Jump to navigation Jump to search
This page contains changes which are not marked for translation.

Other languages:
English
Aripiprazole
Structural formula of aripiprazole
Ball-and-stick model of the aripiprazole molecule
Clinical data
Pronunciation
AIR-i-PIP-rə-zohl
Abilify
ə-BIL-i-fy
Trade namesAbilify, others
AHFS/Drugs.comMonograph
MedlinePlusa603012
License data
Pregnancy
category
Routes of
administration
By mouth (tablets, dissolving tablets, solution); IM (including a depot)
Drug classAtypical antipsychotic
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability87%[2][3][4]
Protein binding>99%[2][3][4]
MetabolismLiver (mostly via CYP3A4 and 2D6[2][3][4])
Elimination half-life75 hours (active metabolite is 94 hours)[2][3][4]
ExcretionRenal (27%; <1% unchanged), Faecal (60%; 18% unchanged)[2][3][4]
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
E number{{#property:P628}}
CompTox Dashboard (EPA)
  • {{#property:P3117}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC23H27Cl2N3O2
Molar mass g·mol−1
3D model (JSmol)
 ☒NcheckY (what is this?)  (verify)

Aripiprazole is one of the top selling drugs an atipsychotic medication marketed as Abilify used in the treatment of Psychosis and depression.

Top 100 drugs by sales in the United States


Information about Aripiprazole

Aripiprazole is an atypical antipsychotic used in the treatment of schizophrenia and bipolar illness.

Aripiprazole
Aripiprazole

Liver safety of Aripiprazole

Aripiprazole therapy has not been associated consistently with serum aminotransferase elevations and has yet to be linked to cases of clinically apparent acute liver injury.

Mechanism of action of Aripiprazole

Aripiprazole (ar" i pip' ra zole) is a partial agonist for dopamine type 2 (D2) and serotonin (5-HT1A) receptors and has antagonist activity against serotonin 5HT2A receptors. Aripiprazole is indicated for the therapy of schizophrenia and as either monotherapy or adjunctive therapy for manic and mixed episodes in bipolar disorder, irritability associated with autistic disorder, and as adjunctive treatment with antidepressants for major depressive disorder. Aripiprazole is also indicated for treatment of Tourette disorder.

FDA approval information for Aripiprazole

It was approved for use in the United States in 2002 and is widely used with almost 9 million prescriptions filled yearly.

Dosage and administration for Aripiprazole

Aripiprazole is available as tablets of 2, 5, 10, 15, 20 and 30 mg generically and under the brand name Abilify. It is also available as an oral solution (1 mg/mL), as orally disintegrating tablets (10 and 15 mg) and as a solution for intramuscular injection (7.5 mg/mL). The typical initial dose for adults is 10 to 15 mg daily, increasing to a maximum of 30 mg daily. In addition, an extended release formulation of aripiprazole has been developed and approved for use in schizophrenia. This formulation is given in a dose of 400 mg intramuscularly once monthly and is available under the brand name Abilify Maintenna.

Side effects of Aripiprazole

Aripiprazole is generally well tolerated, but side effects can include restlessness, sedation, tremor, extrapyramidal symptoms, dizziness, blurred vision, headache, fatigue and nausea. weight gain is uncommon. Rare, but potentially severe adverse events include suicidal ideation and behaviors, neuroleptic malignant syndrome, cerebrovascular adverse events in the elderly with dementia, hypersensitivity reactions, and body weight gain with complications of dyslipidemia and diabetes.

Antipsychotic agents

First Generation

Second Generation (Atypicals)

Cost and Coupons - Aripiprazole

Reviews for Aripiprazole

Learn more about Aripiprazole

Latest research - Aripiprazole

PubMed
Clinical trials

External links

Wikipedia
Medicine icon
Medicine icon

This WikiMD article Aripiprazole is a stub. If you are familiar with the topic Aripiprazole, you can help us. Paid editors welcome!

  1. 1.0 1.1
  2. 2.0 2.1 2.2 2.3 2.4
  3. 3.0 3.1 3.2 3.3 3.4
  4. 4.0 4.1 4.2 4.3 4.4
 

Aripiprazole is part of WikiMD's free ^articles!

^Aripiprazole (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available

Other languages:
English