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Absolute risk reduction

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Decrease in risk of a given activity or treatment in relation to a control activity or treatment.

The absolute difference (risk difference) in rates of harmful outcomes between experimental groups (experimental event rate, or EER) and control groups (control event rate, or CER), calculated as the rate of harmful outcome in the control group minus the rate of harmful outcome in the experimental group (CER – EER). Typically used to describe a beneficial exposure or intervention (e.g., if 20% of patients in the control group have an adverse event, as do 10% among treated patients, the ARR or risk difference would be 10% expressed as a percentage or 0.10 expressed as a proportion).

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