Information about Acamprosate
Acamprosate is a synthetic amino acid and a neurotransmitter analogue that is used as an alcohol deterrent in management of alcohol dependence and abuse.
Liver safety of Acamprosate
Acamprosate has not been linked to serum enzyme elevations during therapy and has not been linked to cases of clinically apparent liver injury.
Mechanism of action of Acamprosate
Acamprosate (a kam' proe sate) is N-acetylhomotaurine, a synthetic amino acid analogue similar to gamma aminobutyric acid (GABA) and taurine that has been shown to decrease alcohol craving in animal models. Acamprosate appears to function as a neurotransmitter with GABA agonist and partial glutamate (N-methyl-D-aspartate [NMDA]) antagonist activity, but its precise mechanism of action in decreasing alcohol craving is unknown. When used in a comprehensive alcohol treatment program, acamprosate has been shown to decrease relapse to alcohol use, at least over the short term.
FDA approval information for Acamprosate
Acamprosate was approved for use in the therapy of alcohol dependence and abuse in the United States in 2004.
Brand name for Acamprosate
Acamprosate is available in delayed release tablets of 333 mg generically and under the brand name Campral.
Dosage and administration for Acamprosate
The typical maintenance dose is 666 mg three times daily and it is recommended to be used only as a part of a comprehensive alcohol treatment program.
Side effects of Acamprosate
The most common side effects are fatigue, anorexia, diarrhea, flatulence, nausea, headache, dizziness, insomnia, paresthesia, itching and sweating.
Substance abuse treatment agents
- Acamprosate, Buprenorphine, Disulfiram, Methadone, Nalmefene, Naloxegol, Naloxone, Naltrexone, Nicotine, Varenicline.
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Reviews for Acamprosate
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Latest research (Pubmed)