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Accelerated phase chronic myelogenous leukemia, bcr-abl1 positive

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a phase of chronic myelogenous leukemia characterized by one or more of the following: 1) myeloblasts accounting for 10-19% of the peripheral blood white cells or of the nucleated cells in the bone marrow, 2) peripheral blood basophils at least 20%, 3) persistent thrombocytopenia that is unrelated to therapy, 4) persistent thrombocytosis despite adequate therapy, 5) increasing white blood cell count and increasing spleen size unresponsive to therapy, and/or evidence of clonal evolution. (who, 2001)


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