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Zafirlukast is used to prevent asthma symptoms. Zafirlukast is in a class of medications called leukotriene receptor antagonists (LTRAs). It is also being studied for use in prostate cancer


It belongs to the family of drugs called endothelin-receptor antagonists.

Information about Zafirlukast

Zafirlukast is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma.


Liver safety of Zafirlukast

Zafirlukast has been linked to rare, but occasionally severe cases of acute liver injury.

Mechanism of action of Zafirlukast

Zafirlukast (za" fir loo' kast) is a leukotriene receptor antagonist that binds to the CysLT1 and CysLT2 receptors, thereby interfering with inflammatory pathways that are involved in the pathogenesis of asthma and allergic rhinitis. Pretreatment with single oral doses of zafirlukast inhibits bronchoconstriction and the early-phase and part of the late-phase inflammatory reactions in asthma.

FDA approval information for Zafirlukast

Zafirlukast was approved for use in the treatment of asthma in the United States in 1996, and it continues to be widely used with more than 2 million prescriptions filled yearly. Other leukotriene receptor antagonists include montelukast and pranlukast, but only montelukast is also available in the United States.

Clinical use of Zafirlukast

Current indications include the prophylaxis and chronic treatment of asthma in adults and children (above the age of 5).


Zafirlukast is available in 10 and 20 mg tablets generically and under the brand name Accolate.

Dosage and administration for Zafirlukast

The recommended dosage of zafirlukast in adults and children >12 years is 20 mg twice daily. The recommended dose in children 5 to 11 years is 10 mg twice daily.

Side effects of Zafirlukast

Common side effects include nausea, diarrhea, loss of appetite, itching, flu like symptoms, dyspepsia, abdominal pain, headache, dizziness, myalgias, and fever.

Brand names

Accolate® Beta-2 Adrenergic Agonists

Albuterol, Bitolterol, Formoterol, Metaproterenol, Pirbuterol, Salbutamol, Salmeterol, Terbutaline

Leukotriene Receptor Antagonists

Montelukast, Zafirlukast

Monoclonal Antibodies

Benralizumab, Mepolizumab, Omalizumab, Reslizumab

Xanthine Derivatives

Theophylline Zileuton

Cost and Coupons - Zafirlukast

Reviews for Zafirlukast

Learn more about Zafirlukast

Latest research (Pubmed)


External links


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