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Acebutolol
Information about Acebutolol
Acebutolol is a cardioselective beta-blocker used in the treatment of hypertension, angina pectoris and cardiac arrhythmias.
Liver safety of Acebutolol
Acebutolol has been linked to several instances of clinically apparent drug induced liver injury.
Mechanism of action of Acebutolol
Acebutolol (a" se bue' toe lol) is considered a “selective” beta-adrenergic receptor blocker in that it has potent activity against beta-1 adrenergic receptors which are found in cardiac muscle, but has little or no activity against beta-2 adrenergic receptors found on bronchial and vascular smooth muscle. Acebutolol also has mild sympathomimetic activity (a partial adrenergic agonist, similar to pinolol).
FDA approval information for Acebutolol
Acebutolol was approved for use in the United States in 1985 and is currently used in the therapy of hypertension alone or in combination with other agents. It is also used for cardiac arrhythmias.
FDA approval information for Acebutolol
Acebutolol is available in capsules of 200 and 400 mg in generic forms and under the trade name Sectral. The usual initial oral dose of acebutolol in adults is 200 mg once or twice daily, with subsequent adjustment based upon clinical response and tolerance; the usual maintenance dosage being 200 to 1200 mg daily.
Side effects of Acebutolol
Common side effects include bradycardia, hypotension, fatigue, dizziness, depression, insomnia, memory loss and impotence. In high doses, acebutolol is less cardioselective and can induced acute bronchospasm. As with other beta-blockers, sudden withdrawal can trigger rebound hypertension.
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