Information about Perindopril
Perindopril is an angiotensin-converting enzyme (ACE) inhibitor used in the therapy of hypertension and stable coronary artery disease.
Liver safety of Perindopril
Perindopril is associated with a low rate of transient serum aminotransferase elevations and has been linked to rare instances of acute liver injury.
Clinical use of Perindopril
Perindopril (per in' doe pril) is an ACE inhibitor which is approved for use alone and in combination with other agents in the therapy of hypertension. Like other ACE inhibitors, perindopril inhibits the conversion of angiotensin I, a relatively inactive molecule, to angiotensin II which is the major mediator of vasoconstriction and volume expansion induced by the renin-angiotensin system. Other host enzymes besides that which converts angiotensin I to II may be inhibited as well, which may account for some of the side effects of the ACE inhibitors.
FDA approval information for Perindopril
Perindopril was approved for use in the United States in 1993, and current indications are for therapy of hypertension and to reduce the risk of cardiovascular mortality in patients with stable coronary artery disease.
Dosage and administration for Perindopril
Perindopril is available in 2, 4 and 8 mg tablets in generic forms and under the trade name Aceon. The typical daily dose in adults is 4 to 8 mg in one or two divided doses, which is administered long term. Common side effects include dizziness, fatigue, headache, cough, gastrointestinal upset and skin rash.
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