Doctor in scrubs


W8MD Diet | COVID-19 portal | Vitamin D | Vaccine | Keto

WikiMD is the world's largest medical encyclopedia with
13,990 pages, 4,158,316 edits & 43,278,125 views.

Free unbiased diet, health and wellness info!

Rabeprazole

From WikiMD's free health, diet & wellness encyclopedia
(Redirected from Aciphex)
Jump to navigation Jump to search
Other languages:
English

Information about Rabeprazole

Rabeprazole is a proton pump inhibitor (PPI) and a potent inhibitor of gastric acidity used in the therapy of gastroesophageal reflux and peptic ulcer disease. 

Rabeprazole
Rabeprazole

Liver safety of Rabeprazole

Rabeprazole therapy is associated with a low rate of transient and asymptomatic serum aminotransferase elevations and is a rare cause of clinically apparent liver injury.

Mechanism of action of Rabeprazole

Rabeprazole (ra bep' ra zole), like other PPIs, binds to and inactivates the H+/K+-ATPase of gastric parietal cells, causing inhibition of the proton pump that transports H+ into the gastric lumen, the final common step in gastric acid production.  Rabeprazole is a prodrug and is converted to the active form in the acidic secretory canaliculi of parietal cells.  Because the inhibition is irreversible, acid secretion is suppressed for 24 to 48 hours, until new proton pump molecules have been synthesized and transported to the cell membrane. 

FDA approval information for Rabeprazole

Rabeprazole was the third PPI approved for use in the United States (1999) and is widely used in the therapy of acid-peptic disease, including duodenal and gastric ulcer disease and gastroesophageal reflux. 

Dosage and administration for Rabeprazole

Rabeprazole is available in delayed release tablets of 20 mg in generic forms and under the brand name Aciphex.  The typical dose for duodenal ulcer disease is 20 mg once daily for 4 to 8 weeks, with similar doses for long term maintenance therapy.  Twice daily doses are used for more severe cases of gastrointestinal reflux and peptic ulcer disease, and doses of up to 120 mg daily for Zollinger-Ellison syndrome. 

Side effects of Rabeprazole

Rabeprazole is very well tolerated.  Side effects are uncommon and usually mild; they may include nausea, vomiting, abdominal discomfort, constipation, diarrhea, flatulence, skin rash, headaches and dizziness.  Severe side effects are rare but can include hypersensitivity reactions.  Long-term use of rabeprazole may be associated with bone fractures, acute interstitial nephritis, lupus erythematosus, vitamin B12 deficiency and hypomagnesemia

The antiulcer agents in clinical use

Proton Pump Inhibitors

Selective Histamine Type 2 Receptor Antagonists or H2 Blockers

Cost and Coupons - Rabeprazole

Reviews for Rabeprazole

Learn more about Rabeprazole

Latest research - Rabeprazole

PubMed
Clinical trials

External links

Wikipedia
Medicine icon
Medicine icon

This WikiMD article Rabeprazole is a stub. If you are familiar with the topic Rabeprazole, you can help us. Paid editors welcome!

 

Rabeprazole is part of WikiMD's free ^articles!

^Rabeprazole (article) is provided for informational purposes only. No expressed or implied warranties as to the validity of content.
WikiMD is not a substitute for professional advice. By accessing and using WikiMD you agree to the terms of use.
Templates etc. when imported from Wikipedia, are licensed under CC BY-SA 3.0. See full disclaimers.
W8MD weight loss logo

Ad. Tired of being overweight?. W8MD's physician weight loss program can HELP. Tele medicine available

Other languages:
English