Acquired epileptiform aphasia
Landau-Kleffner syndrome (LKS)
It is a rare, childhood neurological disorder
EEG abnormalities in LKS
The EEG typcally shows an increase to nearly continuous abnormal brain activity firing (spikes) during sleep that scientists believe impair memory formation.
Part of the brain affected in LKS
The disorder usually occurs in children between the ages of 5 and 7 years.
Typically, children with LKS develop normally but then lose their language skills for no apparent reason.
Seizures in LKS
While many of the affected individuals have seizures, some do not.
The disorder can be difficult to diagnose and may be misdiagnosed and should be recognized as different from the more common causes of autism, pervasive developmental disorder, hearing impairment, learning disability, auditory/verbal processing disorder, attention deficit disorder, childhood schizophrenia, or emotional/behavioral problems.
- The prognosis for children with LKS varies.
- Some affected children may have a permanent severe language disorder, while others may regain much of their language abilities (although it may take months or years).
Remission and relapse
In some cases, remission and relapse may occur. The prognosis is improved when the onset of the disorder is after age 6 and when speech therapy is started early. Seizures generally disappear by adulthood, and the distinctive epilepsy activity on EEG also tends to improve by that time.
Treatment for LKS usually consists of anti-seizure medications and corticosteroids, and speech therapy, which should be started early. A controversial treatment option involves a surgical technique called multiple subpial transection in which the pathways of abnormal electrical brain activity are severed.