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Corticorelin

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Corticorelin
Corticorelin.png
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
CAS Number
PubChem CID
UNII
E number{{#property:P628}}
CompTox Dashboard (EPA)
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Chemical and physical data
FormulaC205H339N59O63S
Molar mass4670.31 g/mol g·mol−1
  (verify)

Corticorelin is a diagnostic agent. It is a corticotropin-releasing hormone.[1]

The corticorelin stimulation test helps to differentiate between the etiologies of ACTH-dependent hypercortisolism. It is used to evaluate the status of the pituitary-adrenal axis in the differentiation of a pituitary source from an ectopic source of excessive ACTH secretion.

  • If corticorelin injection increases plasma levels of ACTH and cortisol, a diagnosis of Cushing's disease is achieved (ACTH of pituitary origin).
  • If corticorelin injection leads to little or no response in plasma levels of ACTH or cortisol, a diagnosis of Ectopic ACTH syndrome is confirmed.

See also

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