Liver safety of Doxycycline
Doxycycline is a semisynthetic, tetracycline related bacteriostatic antibiotic that has been linked to rare instances of acute cholestatic liver injury.
Mechanism of action of Doxycycline
Doxycycline (dox" i sye' kleen) is a semisynthetic tetracycline that is used for mild-to-moderate infections due to susceptible organisms. Doxycycline, like other tetracyclines, is active against a wide spectrum of gram-positive and gram-negative bacteria as well as against several rickettsia, spirochetes, chlamydia and mycoplasma.
Clinical use of Doxycycline
Unlike tetracycline and oxytetracycline, doxycycline has excellent oral availability and wide tissue penetration. Indications include upper respiratory, skin, or soft tissue infections due to susceptible bacteria, gonorrhea and syphilis in penicillin-allergic patients, non-gonococcal urethritis, acute pelvic inflammatory disease, epididymitis, oorchitis, Lyme disease, and as prophylaxis against traveler’s diarrhea. Doxycycline is also used chronically as treatment of acne.
FDA approval information for Doxycycline
Doxycycline was approved for use in the United States in 1967 and is still widely used, with more than 11 million prescriptions filled yearly. Doxycycline is available in multiple generic forms in capsules and tablets ranging from 20 to 100 mg, and as oral suspensions for pediatric use. Typical adult doses are 100 to 200 mg twice daily for 7 to 30 days. Parenteral forms for intravenous or intramuscular administration are also available.
Brand name for Doxycycline
Trade names for doxycycline include Vibramycin, Oracea, Adoxa, Monodox and Doxycin.
Side effects of Doxycycline
Common side effects include headache, dizziness, nausea, gastrointestinal upset, skin and tooth discoloration and rash. List of tetracyclines
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Learn more about Doxycycline
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