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Information about Triprolidine

Triprolidine is a first generation antihistamine that is used for symptoms of allergic rhinitis and the common cold and as a short acting sedative.


Liver safety of Triprolidine

Triprolidine has not been linked to instances of clinically apparent acute liver injury.

Mechanism of action of Triprolidine

Triprolidine (trye proe' li deen) is a first generation antihistamine that is used to treat the symptoms of the common cold, including sneezing, cough, runny note, watery eyes and itching. Triprolidine belongs to the ethanolamine class of antihistamines (with clemastine and dimenhydrinate) and is currently used largely in combination with pseudoephedrine in prescription or over-the-counter products for relief of symptoms of the common cold and allergic rhinitis.

Brand name for Triprolidine

Representative brand names of products that include triprolidine include Aprodine and Silafed.

Dosage and administration for Triprolidine

The typical adult oral dose is 2.5 mg 3 to 4 times a day.

Side effects of Triprolidine

Common side effects include sedation, impairment of motor function, confusion, dizziness, blurred vision, dry mouth and throat, palpitations, tachycardia, abdominal distress, constipation and headache. Antihistamines can worsen urinary retention and glaucoma.

First Generation Antihistamines

Second Generation Antihistamines

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