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Alteplase

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alteplase

A recombinant therapeutic agent which is chemically identical to or similar to endogenous tissue plasminogen activator (tPA). tPA is a serine protease which converts plasminogen to plasmin, a fibrinolytic enzyme. Upon administration, alteplase increases plasmin enzymatic activity, resulting in hyperfibrinolysis and potential dissolution of a thrombus or embolism.

Synonym

  • recombinant tissue plasminogen activator
  • t-PA

US brand name

  • Activase

Abbreviation

rt-PA

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