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An oral medication used to treat diabetes.

Information about Pioglitazone

Pioglitazone is an insulin sensitizing agent and thiazolidinedione that is indicated for the treatment of type 2 diabetes.


Liver safety of Pioglitazone

Pioglitazone has been linked to rare instances of acute liver injury. While the initial thiazolidinedione approved for use – troglitazone – was associated with high rates of serum aminotransferase elevations and multiple reports of severe liver injury and death from acute liver failure, pioglitazone has been associated with only rare instances of clinically apparent liver injury.

Mechanism of action of Pioglitazone

Pioglitazone (pye" oh gli' ta zone) is a thiazolidinedione thought to act by engagement of PPAR-? receptors which induce multiple genes involved in glucose and fatty acid metabolism. In clinical trials, pioglitazone was found to lower blood glucose and HbA1c levels and had additive effects with the sulfonylureas and metformin.

FDA approval information for Pioglitazone

Pioglitazone was approved for use in the United States in 1999 and remains in wide use. Current indications for pioglitazone are as an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes.

Dosage and administration for Pioglitazone

Pioglitazone is available in 15, 30 and 45 mg tablets generically and under the brand name Actos, and as a fixed combination with metformin (Actoplus Met and others) and with glimepiride (Duetact and others).

The recommended dosage is 15 to 45 mg once daily. Pioglitazone is used as monotherapy as well as in combination with metformin, sulfonylureas or insulin.

Side effects of Pioglitazone

Common side effects of pioglitazone include weight gain and edema.


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