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Acute cortical necrosis

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Acute kidney injury caused by ischemic necrosis of the renal cortex. Renal cortex is very sensitive to hypoxia.

Kidney – acute cortical necrosis
Kidney – acute cortical necrosis

Causes

Acute cortical necrosis can be caused many factors including vascular disease, infections, autoimmune problems, trauma, alcohol, pregnancy, to name a few and include the following:

  • Acute tubular necrosis
  • Autoimmune kidney disease
  • Blood clot from cholesterol
  • Decreased blood flow due to very low blood pressure due to burns, dehydration, hemorrhage, injury, septic shock, serious illness, or surgery
  • Disorders that cause clotting within the kidney blood vessels
  • Infections that directly injure the kidney, such as acute pyelonephritis or septicemia
  • Pregnancy complications, including placenta abruption or placenta previa
  • Urinary tract blockage
  • Illicit drugs such as cocaine and heroine
  • Medicines including non-steroidal anti-inflammatory drugs (NSAIDs), certain antibiotics and blood pressure medicines, intravenous contrast (dye), some cancer and HIV drugs
Renal cortical infarction showing coagulative necrosis
Renal cortical infarction showing coagulative necrosis

Symptoms

  • Bloody stools
  • Breath odor and metallic taste in the mouth
  • Bruising easily
  • Changes in mental status or mood
  • Decreased appetite
  • Fatigue or slow sluggish movements
  • Flank pain (between the ribs and hips)
  • High blood pressure  
  • Nausea or vomiting, may last for days
  • Swelling due to the body keeping in fluid
  • Urination changes, such as little or no urine

Kidney ultrasound
Kidney ultrasound

Investigations

Treatment

Treatment depends on the cause and rapid reversal of the cause can lead to full recovery.

Alternative Names

  • Diffuse bilateral renal cortical necrosis (BRCN)
  • Diffuse cortical necrosis
  • Acute cortical necrosis
  • Acute kidney failure with acute cortical necrosis
Health science - Medicine - Nephrology - edit
Diseases of the glomerulus
Lupus nephritis | Post-infectious glomerulonephritis | Minimal change disease | Focal segmental glomerulosclerosis | Diabetic nephropathy
Diseases of the proximal convoluted tubules
Fanconi syndrome (Type II renal tubular acidosis) | renal cell carcinoma
Diseases of the distal convoluted tubules
pseudohypoaldosteronism (Type IV renal tubular acidosis)
Diseases of the collecting duct
Type I renal tubular acidosis
Tumours of the kidney
renal cell carcinoma | Wilms' tumour (children)
Diseases of the renal vasculature
renal artery stenosis | vasculitis | atheroembolic disease
Tubulointerstitial diseases of the kidney
Drug-induced interstitial nephritis | Obstructive nephropathy | Radiation nephritis | Reflux nephropathy | Sarcoidosis
Genetic diseases of the kidney/syndromes associated with kidney dysfunction
Alport syndrome | Polycystic kidney disease | Wilms' tumour (children)

von Hippel-Lindau syndrome | Hereditary papillary renal carcinoma | Birt-Hogg-Dube syndrome | Hereditary renal carcinoma

Genetic diseases of the kidney/syndromes associated with kidney dysfunction

Chronic Kidney Disease

Anemia in CKD | Causes of CKD | CKD Overview | CKD Tests and Diagnosis | Diabetic Kidney Disease | Eating Right for CKD | High Blood Pressure and Kidney Disease | Managing CKD | Mineral and Bone Disorder in CKD | Nutrition for Advanced CKD in Adults | Preventing CKD | Quick Reference on UACR & GFR

Kidney Failure

Eating and Nutrition for Hemodialysis | Financial Help for Treatment of Kidney Failure | Hemodialysis | Kidney Failure | Kidney Transplant | Peritoneal Dialysis

Other Kidney Topics

Acquired Cystic Kidney Disease | Amyloidosis and Kidney Disease | Diabetes Insipidus | Ectopic Kidney | Glomerular Diseases | Goodpasture Syndrome | Henoch-Schönlein Purpura | IgA Nephropathy | Kidney Dysplasia | Kidney Infection (Pyelonephritis) | Kidney Stones | Lupus Nephritis | Medullary Sponge Kidney | Nephrotic Syndrome in Adults | Pain Medicine and Kidney Damage | Polycystic Kidney Disease (PKD) | Renal Artery Stenosis | Renal Tubular Acidosis | Simple Kidney Cysts | Solitary Kidney | Your Kidneys and How They Work | Your Urinary Tract and How It Works

 

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